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Descrizione

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Autore: Kovalchuk
Editore: Academic Press (Elsevier Group)
Data di Pubblicazione: 2016
ISBN: 9780128033098
Pagine: 712

Key Features

• Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects
• Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability
• Contains applications of genome instability and its effect on human diseases
• Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

Description

Genome Stability: From Virus to Human Application covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging.

Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species.

This book teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. The book also covers how epigenetic factors contribute to genome stability and how species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner.